Professor Oregon State University Corvallis, Oregon, United States
Effects on the developing immune system from exposure to pharmaceutical agents may occur at lower doses than effects on the adult immune system and also may have lifelong impacts. However, detecting changes in the developing immune system can be challenging if the timing of exposure is not appropriately paired with relevant endpoints to detect developmental immunotoxicity (DIT). This talk will focus on current assessment tools available for evaluation of DIT, including descriptions of vulnerable windows of developmental exposure, robust endpoints for detecting DIT, and the potential for new approach methodologies to provide data to enhance understanding of potential risks to exposed subjects.
